CAI Yan, WU Jie, Kalkabay Gulnar, ZHANG Hong-yi, CAO Jin-feng, XU Shi-xiong, Quan Long, M. W. Collins. Numerical Simulation of Solid Tumor Angiogenesis With Endostatin Treatment: a Combined Analysis of Anti-Angiogenic Factor Inhibiting Effect and Extra-Cellular Matrix Micro Mechanical Environment[J]. Applied Mathematics and Mechanics, 2009, 30(10): 1165-1172. doi: 10.3879/j.issn.1000-0887.2009.10.004
Citation: CAI Yan, WU Jie, Kalkabay Gulnar, ZHANG Hong-yi, CAO Jin-feng, XU Shi-xiong, Quan Long, M. W. Collins. Numerical Simulation of Solid Tumor Angiogenesis With Endostatin Treatment: a Combined Analysis of Anti-Angiogenic Factor Inhibiting Effect and Extra-Cellular Matrix Micro Mechanical Environment[J]. Applied Mathematics and Mechanics, 2009, 30(10): 1165-1172. doi: 10.3879/j.issn.1000-0887.2009.10.004

Numerical Simulation of Solid Tumor Angiogenesis With Endostatin Treatment: a Combined Analysis of Anti-Angiogenic Factor Inhibiting Effect and Extra-Cellular Matrix Micro Mechanical Environment

doi: 10.3879/j.issn.1000-0887.2009.10.004
  • Received Date: 2009-01-06
  • Rev Recd Date: 2009-08-19
  • Publish Date: 2009-10-15
  • To investigate the in fluence of anti-angiogenesis drug Endostatin to solid tumor angiogenesis, a mathe matical model of tumor angiogenesis was developed with combined influences of local extra-cellular matrix mechanical environment, and the inhibiting effects of Angiostatin and Endostatin. The simulation results show that Angiostat in and Endostatin caneffectively inhibit the process of tumor angiogenesis, and decrease the number of blood vessels in the tumor. The present model could be used as a valid theoreticalm ethod in the investigation of anti-angiogenic therapy of tumors.
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