基于人工免疫网络的药代动力学参数优化方法

刘丽; 周少丹; 卢红文; 谢芬; 须文波

基于人工免疫网络的药代动力学参数优化方法

1.
江南大学信息工程学院,江苏无锡 214122;2.苏州大学附属第四医院,无锡市第四人民医院,江苏无锡 214036

基金项目: 江苏省卫生厅基金资助项目(P200512)

详细信息

作者简介:
刘丽(1975- ),女,天津人,讲师,博士研究生(联系人.E-mail:liuli_sytu@hotmail.com);周少丹(1966- ),女,无锡人,主管药司;卢红文(1971- ),男,淮安人,主管药师;谢芬(1979- ),湖北天门人,药师;须文波(1946- ),男,无锡人,教授,博士生导师.

中图分类号: TP273
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出版历程
- 收稿日期: 2007-10-10
- 修回日期: 2008-02-27
- 刊出日期: 2008-04-15

Parameter Optimization of Pharmacokinetics Based on Artificial Immune Network

1.
School of Information Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China;

摘要

摘要: 提出了基于人工免疫网络优化药代动力学参数的PKAIN算法．新增的分组并发单纯形变异用以提高人工免疫网络的局部搜索能力．通过PKAIN人工免疫网络中网络细胞的进化得到给定药代动力学模型的一组优化参数．应用Laplace变换求解瑞芬太尼(remifentanil)及其代谢产物瑞芬太尼酸的联合代谢动力学模型的微分方程组，通过PKAIN算法优化导出房室模型参数A·D2实验表明，对伴有轻度肾损伤病人可以应用二室模型描述瑞芬太尼酸的药代动力学特征．
- 人工免疫网络 /
- 药代动力学 /
- 房室模型 /
- 单纯形 /
- 瑞芬太尼
Abstract: A new method for parameter optimization of pharmacokinetics based on artificial immune network named PKAIN is proposed.To improve local searching ability of the artificial immune network,a partition-based concurrent simplex mutation is developed.By means of evolution of network cells in the PKAIN artificial immune network,an optimal set of parameters of a given pharmacokinetic model was obtained.The Laplace transform was applied to the pharmacokinetic differential equations of remifentanil and its major metabolite,remifentanil acid.The PKAIN method was used to optimize parameters of the derived compartment models.Experimental results show that two-compartment model is sufficient for the pharmacokinetic study of remifentail acid for patients with mild degree of renal impairment.
- artificial immune network /
- pharmacokinetics /
- compartment model /
- simplex /
- remifentanil

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参考文献(26)

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基于人工免疫网络的药代动力学参数优化方法

作者简介:
刘丽(1975- ),女,天津人,讲师,博士研究生(联系人.E-mail:liuli_sytu@hotmail.com);周少丹(1966- ),女,无锡人,主管药司;卢红文(1971- ),男,淮安人,主管药师;谢芬(1979- ),湖北天门人,药师;须文波(1946- ),男,无锡人,教授,博士生导师.

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Parameter Optimization of Pharmacokinetics Based on Artificial Immune Network

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基于人工免疫网络的药代动力学参数优化方法

作者简介: 刘丽(1975- ),女,天津人,讲师,博士研究生(联系人.E-mail:liuli_sytu@hotmail.com);周少丹(1966- ),女,无锡人,主管药司;卢红文(1971- ),男,淮安人,主管药师;谢芬(1979- ),湖北天门人,药师;须文波(1946- ),男,无锡人,教授,博士生导师.

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Parameter Optimization of Pharmacokinetics Based on Artificial Immune Network

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出版历程

目录

作者简介:
刘丽(1975- ),女,天津人,讲师,博士研究生(联系人.E-mail:liuli_sytu@hotmail.com);周少丹(1966- ),女,无锡人,主管药司;卢红文(1971- ),男,淮安人,主管药师;谢芬(1979- ),湖北天门人,药师;须文波(1946- ),男,无锡人,教授,博士生导师.