Mass Transport in Solid Tumors(Ⅱ)——Drug Delivery
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摘要: 本文提出肿瘤中药物传输的三重介质模型.基于第(Ⅰ)部分流体动力学的计算结果,采用有限元方法,在不同初始和边界条件下求解了对流-扩散方程组.根据计算结果,详细分析了药物注射方式、分子量、淋巴、药物结合和坏死区等对抗体免疫球蛋白IgG及其片断Fab在肿瘤中浓度分布的影响.Abstract: Based on the flow field solution of the three-porous-medium model for tumor microcirculation,the diffusion-convection equations are solved with varions initial and boundary conditions using finite element method.The concentration profile of two therapeutic agents immunoglobulin G(lgG) and its antigen-binding fragment(Fab) in blood,lymph and intersitial flaid are obtained for normal-tissue-surrounded tumor.The effect of tumor microvasculature,lymph function,drug injection mode,the molecular weight and binding kinetics of the drug on the distribution in tumors are considered.
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Key words:
- three-porous-medium model /
- solid tumor /
- drug delivery /
- diffusion-convection equations /
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[1] O.Kedem and A,Katchalsky,Thermodynamic analysis of the permeability of biological membranes to non-electrolytes,Biochemical ET Biophysica Acta.,27(1958),229-254. [2] L.T.Baxter and R.K.Jaai.Transport of fluid and macromolecules in tumors I,Role of interstitial pressure and convection.Microvascular Res.,37.1(1989),77-104. [3] L.T.Baxter and R.K.Jain,Transport of fluid and macromolecules in tumors Ⅱ,Role of heterogeneous perfusion and lymphatics,Microvascular Res.,40,2(1990),246-263. [4] L.T.Baxter and R.K.Jain,Transport of fluid and macromolecules in tumors Ⅲ,Role of binding and metabolism,Microvascular Res.,41,1(1991),5-23. -
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