Mass Transport in Solid Tumors(Ⅰ)—luid Dynamics
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摘要: 本文提出肿瘤内部液体和药物传质的三重介质模型.在这部分,研究间隙压力和对流的作用.对于孤立肿瘤和被正常组织包围的肿瘤得到了分析解.计算结果与实验一致,即组织间隙的高压是阻碍药物进入肿瘤的主要原因.文章详细分析了降低间隙压力的参数.Abstract: A three-porous-medium model for transvascular exchange and extravascular transport of fluid and macromolecules in a spherical solid tumor is developed. The microvasculature, lymphatics, and tissue space are each treated as a porous medium with the flow of blood, lymph, and interstitial fluid obeying Darcy's law and Starling's assumption. In this part, the role of int erstitial pressure and fluid convection are st udied. The analytical solutions are obtained for the isolated tumor and the normal-tissue-surrounded tumor respectively. The calculated interstitial pressure profile are consistent with the experimental observation that the elevated interstitial pressure is a major barrier in the penetration of macromolecular drug into tumors. The factors which may reduce the interstitial pressure are analyzed in details.
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