前列腺肥大对下尿道内尿液流影响的分析
An Analysis of the Effects of the Prostatic Hypertropy on the Urinary Flow in Lower-Urinary-Tract
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摘要: 本文从下尿道内尿液流动问题的生理背景出发建立起相应的可塌陷管的力学分析模型。通过对此模型的分析发现在Pn—Qn特征曲线的正、负斜率区域内可塌陷管都可能产生自激振荡,从而拓广了Conrad[1],Griffiths[2]和Conrad,Cohen及MeQueen[3]等作者得出的只有在Pn—Qn特征曲线具有负斜率时才会出现自激振荡的结论。本文通过数值计算详细讨论了前列腺肿胀对下尿道内尿液流动参量的影响情况。结果表明,有可能根据膀胱压和出口速度等的变化推测前列腺的肿胀情况,从而为前列腺肿胀提供一种理论上的检测和诊断的方法。Abstract: In this paper an analytic model corresponding to the collapsible tube for analysing the urinary flow in lower-urinary-tract is set up from physiologic background.By analysing the model it is found that the self-excited oscillations can both occur in the region of negative and positive slope of Pn-Qn characteristic. So this paper extends the results of Conrad[1], Griffiths[2], Conrad, Cohen and McQueen[3] and others that the self-excited oscillations can only occur in the region of negative slope of Pn-Qn characteristic. The effects of prostatic hypertropy on the flow parameters in lower-urinary-tract is discussed in detail by numerical calculations. The results show that it is possible to know the conditions of prostatic hypertropy according to the changes of bladder pressure, outlet urinary velocity and other parameters. From these results a theoretical method to detect and diagnose prostatic hypertropy is provided.
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[1] Conrad,W.A.,Pressure-flow relationships in collapsible tubes,IEEE Trans.Bio-Med.Eng.,BME,16(1969),284-295. [2] Griffiths,D.J.,Negative-resistance effects in flow through collapsible tubes:1 Relaxation oscillation,Med.and Bio.Eng.,13(1975) 785-796. [3] Conrad,W.A.,M.L.Cohen and D.M.McQueen,Note on the oscillation of collapsible tubes,Med.Bio.Eng.Comput.,16(1978),211-214. [4] Griffiths,D.J.,The mechanices of the urethra and of micturition,J.Urol.,45(1973),497-507. [5] Smith,J.C.,D.Edwards and G.H.Bryant,A practical method of measuring urethral resistance to micturition,Br.J.Urol.,38(1966),542-546. [6] Pedley,T.J.,The Fluid Mechanics of Large Blood Vessels,Cambridge University(1980). [7] Shapiro,Ascher H.,Steady flow in collapsible tubes,Trans.ASME,Ser.K.,J.Biomech.Eng.,99(1977),126-147. -
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