Abstract: The radial symmetric motion problem was examined for a spherical shell composed of a class of imperfect incompressible hyper-elastic materials, in which the materials may be viewed as the homogeneous incompressible isotropic neo-Hookean material with radial perturbations. A second-order nonlinear ordinary differential equation that describes the radial motion of the inner surface of the shell was obtained. And the first integral of the equation was then carried out. Via analyzing the dynamical properties of the solution of the differential equation, the effects of the prescribed imperfection parameter of the material and the ratio of the inner and the outer radii of the underformed shell on the motion of the inner surface of the shell were discussed, and the corresponding numerical examples were carried out simultaneously. In particular, for some given parameters, it was proved that, there exists a positive critical value, and the motion of the inner surface with respect to time will present a nonlinear periodic oscillation as the difference between the inner and the outer presses does not exceed the critical value. However, as the difference exceeds the critical value, the motion of the inner surface with respect to time will increase infinitely. That is to say, the shell will be destroyed ultimately.