Method on Estimation of Drug's Penetrated Parameters
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摘要: 参考透皮给药的大量实验数据，选择一种非线性回归模型作为相应的数学模型，并通过这一模型中的透皮系数作为被估计的参数完成了这一工作，同时给出了对20种药物的不同渗透系数的估计．最后的讨论中发现，这一工作进一步支持了将皮肤视作单层渗透膜的理论．Abstract: Transdermal drug delivery system(TDDS) is a new method for drug delivery.The analysis of plenty of experiments in vitro can lead to a suitable mathematical model for the description of the process of the drug's penetration through the skin,together with the important parameters that are related to the characters of the drugs.After the research work of the experiments data,a suitable nonlinear regression model was selected.Using this model,the most important parameter-penetrated coefficient of 20 drugs was computed.In the result one can find,this work supports the theory that the skin can be regarded as singular membrane.
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