Method on Estimation of Drug's Penetrated Parameters
-
摘要: 参考透皮给药的大量实验数据，选择一种非线性回归模型作为相应的数学模型，并通过这一模型中的透皮系数作为被估计的参数完成了这一工作，同时给出了对20种药物的不同渗透系数的估计．最后的讨论中发现，这一工作进一步支持了将皮肤视作单层渗透膜的理论．Abstract: Transdermal drug delivery system(TDDS) is a new method for drug delivery.The analysis of plenty of experiments in vitro can lead to a suitable mathematical model for the description of the process of the drug's penetration through the skin,together with the important parameters that are related to the characters of the drugs.After the research work of the experiments data,a suitable nonlinear regression model was selected.Using this model,the most important parameter-penetrated coefficient of 20 drugs was computed.In the result one can find,this work supports the theory that the skin can be regarded as singular membrane.
-
[1] Michniak B B,Player M R,Godwin D A,et al.In vitroevaluation of azone analogsas dermal penetration enhancers—Ⅴ：Miscellaneous compounds[J].Int J Pharm,1998,161(2):169—178. doi: 10.1016/S0378-5173(97)00349-9 [2] Laugel C,Baillet A,Youenang Piemi M P,et al.Oil-water-oil multiple emulsions for prolonged delivery of hydrocortisone after topical application:comparison with simple emulsions[J].Int J Pharm,1998,160(1):109—117. doi: 10.1016/S0378-5173(97)00302-5 [3] FANG Jia-zou,HUANG Yaw-bin,LIN Huang-hong,et al.Transdermal iontophoresis of sodium nonivamide acetate—Ⅳ:Effect of polyrner formulations[J].Int J Pharm,1998,173(2):227—240. [4] Levang A K,ZHAO Kai-di,Singh Jagdish.Effect of ethanol/propylene glycol on the in vitro perceutaneous absorption of aspirin,biophysical changes and macroscopic barrier properties of the skin[J].Int J Pharm,1999,181(2):255—263. doi: 10.1016/S0378-5173(99)00055-1 [5] Saija Antonella,Tomaino Antonio,Trombetta Domenico,et al.Influence of different penetration enhancers on in vitro skin permeation and in vitro photoprotective effect of flavonoids[J].Int J Pharm,1998,173(1):127—140. doi: 10.1016/S0378-5173(98)00213-0 [6] Cornwell P A,Tubek Joe A H P,Van Gompel Hans,et al.Glyceryl monocaprylate/caprate as a moderate skin penetration enhancers[J].Int J Pharm,1998,171(2):243—255. doi: 10.1016/S0378-5173(98)00194-X [7] 朱军.线性回归模型的原理及应用[M].杭州：浙江大学出版社，1998. [8] 张小蒂.应用回归分析[M].杭州：浙江大学出版社，1991. [9] 韦博成.近代非线性回归分析[M].南京：东南大学出版社，1989. [10] Jennrich R I.Aszmptotic Properties of Nonlinear Least Squares Estimators[M].Ann Math Statist,1969. -
点击查看大图
计量
- 文章访问数: 1879
- HTML全文浏览量: 67
- PDF下载量: 837
- 被引次数: 0
下载:
