抗血管生成药物Endostantin作用下实体肿瘤血管生成的数值模拟:考虑基质力学环境及血管生成抑素的影响

蔡彦; 吴洁; 古娜; 张洪一; 曹金凤; 许世雄; 龙泉; 柯林斯

doi:10.3879/j.issn.1000-0887.2009.10.004

抗血管生成药物Endostantin作用下实体肿瘤血管生成的数值模拟:考虑基质力学环境及血管生成抑素的影响

doi: 10.3879/j.issn.1000-0887.2009.10.004

复旦大学力学与工程系,上海 200433;2.布鲁内尔大学布鲁内尔生物工程研究所, 乌克斯桥密德萨斯, 英国

基金项目: 国家自然科学基金资助项目(10372026;10772751);上海市重点学科基金资助项目(B112)

详细信息

作者简介:
蔡彦(1984- ),女,安徽安庆人,博士;许世雄(联系人.Tel:+86-21-65643813;E-mail:xusx@homtail.com).

中图分类号: R318.01;TB115 A
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出版历程
- 收稿日期: 2009-01-06
- 修回日期: 2009-08-19
- 刊出日期: 2009-10-15

Numerical Simulation of Solid Tumor Angiogenesis With Endostatin Treatment: a Combined Analysis of Anti-Angiogenic Factor Inhibiting Effect and Extra-Cellular Matrix Micro Mechanical Environment

Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China;

摘要

摘要: 为研究抗血管生成药物Endostatin作用下，肿瘤血管生成过程中基质力学环境及血管生成抑素的影响，考虑内皮细胞（EC）和细胞外基质（ECM）两相，耦合抗血管生成药物Endostatin和血管生成抑素Angiostatin的抑制效应，建立肿瘤内外血管生成的二维数值模型．抗血管生成因子Angiostatin和药物Endostatin耦合作用时，可明显降低肿瘤组织内的微血管密度，对肿瘤快速生长起到一定的抑制作用．所给出的模型，可以较好模拟基质力学环境影响下，肿瘤抗血管生成因子对内皮细胞迁移和增殖的抑制作用
- 肿瘤血管生成 /
- 抗血管生成药物 /
- 力学环境 /
- 数学模型
Abstract: To investigate the in fluence of anti-angiogenesis drug Endostatin to solid tumor angiogenesis, a mathe matical model of tumor angiogenesis was developed with combined influences of local extra-cellular matrix mechanical environment, and the inhibiting effects of Angiostatin and Endostatin. The simulation results show that Angiostat in and Endostatin caneffectively inhibit the process of tumor angiogenesis, and decrease the number of blood vessels in the tumor. The present model could be used as a valid theoreticalm ethod in the investigation of anti-angiogenic therapy of tumors.
- tumor angiogenesis /
- anti-angiogenesis /
- mechanical environment /
- mathematical model

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参考文献(16)

[1]	Folkman J. Tumor angiogenesis: therapeutic implication [J]. N Engl J Med, 1971, 285(17): 1182-1186. doi: 10.1056/NEJM197111182852108
[2]	陈斌，陈余清. 抗血管生成治疗肿瘤研究的进展 [J]. 国外医学内科学分册, 2006, 33（7）: 290-294.
[3]	O’Reilly M S, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth [J]. Cell, 1997, 88(2): 277-285. doi: 10.1016/S0092-8674(00)81848-6
[4]	O’Reilly M S, Holmgren L, Shing Y, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma [J]. Cell, 1994, 79(2): 315-328. doi: 10.1016/0092-8674(94)90200-3
[5]	ZHU Jun-dong, YU Xiao-ping, MI Man-tian. Genistein inhibits expression of vascular endothelial growth factor in her-2/neu transfected human breast cancer MCF-7 cells [J]. Chinese Journal of Cancer Research, 2006, 18(2): 83-87. doi: 10.1007/s11670-006-0083-0
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[8]	赵改平，高昊，吴洁，等. 抗血管生成因子Angiostatin与Endostatin作用下肿瘤血管生成的二维数值模拟[J]. 医用生物力学, 2006, 21（4）: 272-279.
[9]	蔡彦，古娜，张洪一，等. 基质力学环境影响下实体肿瘤血管生成的二维数值模拟[J].医用生物力学, 2008, 23（6）: 434-440.
[10]	高昊，许世雄，蔡颖，等. 肿瘤血管生成的二维数值模拟[J]. 力学季刊, 2005, 26（3）: 468-471.
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[14]	WU Jie, LONG Quan, XU Shi-xiong, et al. Study of tumor blood perfusion and its variation due to vascular normalization by anti-angiogenic therapy based on 3D angiogenic microvasculature [J]. J Biomechanics, 2009, 42(6): 712-721. doi: 10.1016/j.jbiomech.2009.01.009
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抗血管生成药物Endostantin作用下实体肿瘤血管生成的数值模拟:考虑基质力学环境及血管生成抑素的影响

doi: 10.3879/j.issn.1000-0887.2009.10.004

作者简介:
蔡彦(1984- ),女,安徽安庆人,博士;许世雄(联系人.Tel:+86-21-65643813;E-mail:xusx@homtail.com).

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Numerical Simulation of Solid Tumor Angiogenesis With Endostatin Treatment: a Combined Analysis of Anti-Angiogenic Factor Inhibiting Effect and Extra-Cellular Matrix Micro Mechanical Environment

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抗血管生成药物Endostantin作用下实体肿瘤血管生成的数值模拟:考虑基质力学环境及血管生成抑素的影响

doi: 10.3879/j.issn.1000-0887.2009.10.004

作者简介: 蔡彦(1984- ),女,安徽安庆人,博士;许世雄(联系人.Tel:+86-21-65643813;E-mail:xusx@homtail.com).

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出版历程

Numerical Simulation of Solid Tumor Angiogenesis With Endostatin Treatment: a Combined Analysis of Anti-Angiogenic Factor Inhibiting Effect and Extra-Cellular Matrix Micro Mechanical Environment

计量

出版历程

目录

作者简介:
蔡彦(1984- ),女,安徽安庆人,博士;许世雄(联系人.Tel:+86-21-65643813;E-mail:xusx@homtail.com).