Effects of Renal Artery Stenosis in a Realistic Model of Abdominal Aorta and Renal Arteries Incorporating FSI and Pulsatile Non-Newtonian Blood Flow
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摘要: 研究肾动脉狭窄(RAS)对血液流动和血管壁的影响.根据CT扫描图像,重建腹部主动脉和肾动脉的解剖模型,通过模型的脉动流进行了仿真计算,计算中考虑了流体-固体结构的相互作用(FSI).研究RAS对血管壁剪切应力和位移的影响,RAS使得肾动脉中流量减少,肾素-血管紧缩素系统可能被激活,从而导致严重的高血压.
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关键词:
- 肾动脉狭窄 /
- 脉动 /
- 流体-固体结构的相互作用 /
- 非Newton流体 /
- 高血压
Abstract: The effects of renal artery stenosis (RAS) on blood flow and vessel walls were investigated. Pulsatile blood flow through an anatomically realistic model of abdominal aorta and renal arteries reconstructed from CT-scan images was simulated, incorporating fluid-structure interaction (FSI). In addition to the investigation of RAS effects on wall shear stress and displacement of vessel wall, it was determined that RAS lead to decrease in renal mass flow which may cause the activation of the renin-angiotension system and result in severe hypertension.-
Key words:
- renal artery stenosis /
- pulsatile /
- fluid-structure interaction /
- non-Newtonian /
- hypertension
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