A Molecular Clutch Model of Cellular Adhesion on Viscoelastic Substrate

CHENG Bo; XU Feng

doi:10.21656/1000-0887.420259

Volume 42 Issue 10

Oct. 2021

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CHENG Bo, XU Feng. A Molecular Clutch Model of Cellular Adhesion on Viscoelastic Substrate[J]. Applied Mathematics and Mechanics, 2021, 42(10): 1074-1080. doi: 10.21656/1000-0887.420259

Citation:

CHENG Bo, XU Feng. A Molecular Clutch Model of Cellular Adhesion on Viscoelastic Substrate[J]. Applied Mathematics and Mechanics, 2021, 42(10): 1074-1080. doi: 10.21656/1000-0887.420259

Citation:

CHENG Bo, XU Feng. A Molecular Clutch Model of Cellular Adhesion on Viscoelastic Substrate[J]. Applied Mathematics and Mechanics, 2021, 42(10): 1074-1080. doi: 10.21656/1000-0887.420259

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A Molecular Clutch Model of Cellular Adhesion on Viscoelastic Substrate

doi: 10.21656/1000-0887.420259

CHENG Bo^1,2,
XU Feng^{1,2
,
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1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P.R.China;
2. Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an 710049, P.R.China

Funds:

11761161004

12002262)

The National Natural Science Foundation of China(11972280

Received Date: 2021-08-31
Rev Recd Date: 2021-09-23

Abstract

Abstract

The viscoelastic nature of the microenvironment of a cell is critical to cell mechanobiology, and modulates the mechanical feedback between cells and extracellular matrix. However, the mechanisms underlying the ways that cells actively sense and respond to a viscoelastic microenvironment remain elusive. We therefore developed a molecular clutch model of cell traction to predict the effects of substrate viscoelasticity on the dynamics of focal adhesions connecting the intracellular actin cytoskeleton to a viscoelastic substrate. The model predicts that certain levels of viscoelastic damping can increase cell tractions on relatively compliant substrates, and that this damping reduces cell tractions on relatively stiff substrates. The model predictions are qualitatively consistent well with reported experimental observations. The model offers physical insights into the role of substrate viscoelasticity on cell tractions and cell spreading.
- Viscoelasticity,
- mechanotransduction,
- cell adhesion,
- mechanical microenvironment

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References(19)

References

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