Effects of Cartilage Endplate Degeneration on Metabolic Transport and Biomechanical Responses of Cervical Intervertebral Discs

LIU Jinglong; XU Peng; LI Qiao; WANG Lizhen; FAN Yubo

doi:10.21656/1000-0887.450017

Volume 45 Issue 6

Jun. 2024

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Article Navigation > Applied Mathematics and Mechanics > 2024 > 45(6): 763-774

LIU Jinglong, XU Peng, LI Qiao, WANG Lizhen, FAN Yubo. Effects of Cartilage Endplate Degeneration on Metabolic Transport and Biomechanical Responses of Cervical Intervertebral Discs[J]. Applied Mathematics and Mechanics, 2024, 45(6): 763-774. doi: 10.21656/1000-0887.450017

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Effects of Cartilage Endplate Degeneration on Metabolic Transport and Biomechanical Responses of Cervical Intervertebral Discs

doi: 10.21656/1000-0887.450017

LIU Jinglong^{1, 2
,},
XU Peng^{1, 2},
LI Qiao^{3
,
,},
WANG Lizhen^{1, 2, 4},
FAN Yubo^{1, 3, 4}

1.
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, P.R.China
2.
Hangzhou International Innovation Institute, Beihang University, Hangzhou 311115, P.R.China
3.
School of Engineering Medicine, Beihang University, Beijing 100191, P.R.China
4.
State Key Laboratory of Virtual Reality Technology and Systems, Beihang University, Beijing 100191, P.R.China

Received Date: 2024-01-25
Rev Recd Date: 2024-05-09
Publish Date: 2024-06-01

Abstract

Abstract

The fluid flow in the cartilage endplate (CEP) is the main path of nutrient supply and metabolic waste transport within the intervertebral disc (IVD). The increased stiffness, the decreased permeability and the water content of the degenerated cartilage endplate influence the mechanical responses and material transport within the IVD. A porous finite element model for C5-C6 of the cervical spine was established based on the computed tomography (CT) images of an adult. After validation, loads of compression, flexion, extension, axial rotation and lateral bending were applied to this model to calculate the instantaneous responses of the IVD. The calcification and sclerosis in the CEP were simulated with increase of its modulus and decrease of its permeability and porosity, compared with a healthy case. The results show that, the pore pressures within the CEP and the nucleus pulposus (NP) increase and the fluid velocity decrease in the degenerated CEP. Under flexion, the pore pressure in the NP increase by 50.8% and 88.9% in calcified and sclerotic CEPs compared to the healthy endplate, respectively. The decreases of the permeability and the water content in the degenerated CEP hinder the fluid flow and increase the maximum principal stresses of the NP matrix by 122.2% and 100.0% under compression and axial rotation, respectively.
- cartilage endplate degeneration,
- porous media modeling,
- fluid porous pressure,
- numerical simulation

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References(33)

References

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