RONG Weifeng, WANG Rubin. Neurodynamic Analysis of Cochlear Hair Cell Activity[J]. Applied Mathematics and Mechanics, 2019, 40(2): 139-149. doi: 10.21656/1000-0887.390184
Citation: RONG Weifeng, WANG Rubin. Neurodynamic Analysis of Cochlear Hair Cell Activity[J]. Applied Mathematics and Mechanics, 2019, 40(2): 139-149. doi: 10.21656/1000-0887.390184

Neurodynamic Analysis of Cochlear Hair Cell Activity

doi: 10.21656/1000-0887.390184
Funds:  The National Natural Science Foundation of China(11232005;11472104)
  • Received Date: 2018-06-28
  • Rev Recd Date: 2018-07-25
  • Publish Date: 2019-02-01
  • To understand the neurodynamic mechanism of cochlear hair cell activity more profoundly, a hair cell model based on the Hodgkin-Huxley equation was established. Through numerical simulation, neurodynamic analysis of hair cell membrane potential, power, and energy consumption was performed. The results show that, when the sound frequency is in the range of 0.1~20 kHz, the attenuation of outer hair cells’ (OHCs) membrane potential will be lower than that of inner hair cells (IHCs), while the gains in power and energy consumption of OHCs will be much larger than those of IHCs. The low attenuation of OHC membrane potential and the high gains in power and energy consumption support the view that the OHC amplification is driven by electromotility. The study on membrane potential, power and energy consumption of cochlear hair cell contributes to the profound understanding of the neurodynamic properties of hair cell activity.
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  • [1]
    BEAR M F, CONNORS B W, PARADISO M A. Neuroscience: Exploring the Brain [M]. Philadelphia: Williams & Wilkins, 2006.
    梁之安. 听觉感受和辨别的神经机制[M]. 上海: 上海科技教育出版社, 1999.(LIANG Zhian. Neural Mechanisms of Auditory Perception and Discrimination [M]. Shanghai: Shanghai Science and Technology Education Press, 1999.(in Chinese))
    KANDEL E, SCHWARTZ J, JESSELL T, et al. Principles of Neural Science [M]. 5th ed. McGraw-Hill Education Press, 2013.
    ZHAO J, DENG B, QIN Y, et al. Weak electric fields detectability in a noisy neural network[J]. Cognitive Neurodynamics,2017,11(1): 81-90.
    LI X, ZHANG Y, LI L, et al. Attention is shaped by semantic level of event-structure during speech comprehension: an electroencephalogram study[J]. Cognitive Neurodynamics,2017,11(5): 467-481.
    JR NADOL J B. Hearing loss[J]. The New England Journal of Medicine,1993,329(15): 1092-1102.
    HUANG M, JIN J, ZHANG Y, et al. Usage of drip drops as stimuli in an auditory P300 BCI paradigm[J]. Cognitive Neurodynamics,2018,12(1): 85-94.
    FETTIPLACE R, FUCHS P A. Mechanisms of hair cell tuning[J]. Annual Review of Physiology,1999,61: 809-834.
    LAVIGNE F, LONGRE D, MAYAFFRE D, et al. Semantic integration by pattern priming: experiment and cortical network model[J]. Cognitive Neurodynamics,2016,10(6): 513-533.
    FETTIPLACE R, HACKNEY C M. The sensory and motor roles of auditory hair cells[J]. Nature Reviews Neuroscience,2006,7(1): 19-29.
    YUVARAJ R, MURUGAPPAN M. Hemispheric asymmetry non-linear analysis of EEG during emotional responses from idiopathic Parkinson’s disease patients[J]. Cognitive Neurodynamics,2016,10(3): 225-234.
    BEURG M, FETTIPLACE R, NAM J H, et al. Localization of inner hair cell mechanotransducer channels using high speed calcium imaging[J]. Nature Neuroscience,2009,12(5): 553-558.
    HWANG J H, NAM K W, JANG D P, et al. Effects of spectral smearing of stimuli on the performance of auditory steady-state response-based brain-computer interface[J]. Cognitive Neurodynamics,2017,11(6): 515-527.
    COREY D P, HUDSPETH A J. Ionic basis of the receptor potential in a vertebrate hair cell[J]. Nature,1979,281(5733): 675-677.
    HUDSPETH A J. How the ear’s works work[J]. Nature,1989,341(6241): 397-404.
    YI G S, WANG J, DENG B, et al. Complexity of resting-state EEG activity in the patients with early-stage Parkinson’s disease[J]. Cognitive Neurodynamics,2017,11(2): 147-160.
    RUBEL E W, FURRER S A, STONE J S. A brief history of hair cell regeneration research and speculations on the future[J]. Hearing Research,2013,297(1): 42-51.
    HAKAK A M, BHATTACHARYA J, BILORIA N, et al. Navigating abstract virtual environment: an eeg study[J]. Cognitive Neurodynamics,2016,10(6): 471-480.
    BROWNELL W E, BADER C R, BERTRAND D, et al. Evoked mechanical responses of isolated cochlear outer hair cells[J]. Science,1985,227(4683): 194-196.
    BROWNELL W E. What is electromotility? The history of its discovery and its relevance to acoustics[J]. Acoustics Today,2017,13(1): 20-27.
    ASHMORE J. Cochlear outer hair cell motility[J]. Physiological Reviews,2008,88(1): 173-210.
    HOWARD J, HUDSPETH A A J. Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the Bullfrog’s saccular hair cell[J]. Neuron,1988,1(3): 189-199.
    MOUNTAIN D C, CODY A R. Multiple modes of inner hair cell stimulation[J]. Hearing Research,1999,132(1/2): 1-14.
    HODGKIN A L, HUXLEY A F. A quantitative description of membrane current and its application to conduction and excitation in nerve[J]. Bulletin of Mathematical Biology,1952,52(1/2): 25-72.
    CATACUZZENO L, FIORETTI B, FRANCIOLINI F. Voltage-gated outward K currents in frog saccular hair cells[J].Journal of Neurophysiology,2003,90(6): 3688-3701.
    CATACUZZENO L, FIORETTI B, PERIN P, et al. Spontaneous low-frequency voltage oscillations in frog saccular hair cells[J]. Journal of Physiology,2004,561(3): 685-701.
    HAN L, NEIMAN A B. Spontaneous oscillations, signal amplification, and synchronization in a model of active hair bundle mechanics[J]. Physical Review E,2010,81(4): 041913. DOI: 10.1103/PhysRevE.81.041913.
    NEIMAN A B, KAI D, BENJAMIN L, et al. Spontaneous voltage oscillations and response dynamics of a Hodgkin-Huxley type model of sensory hair cells[J]. Journal of Mathematical Neuroscience,2011,1(11): 1-24.
    MISTRK P, MULLALEY C, MAMMANO F, et al. Three-dimensional current flow in a large-scale model of the cochlea and the mechanism of amplification of sound[J]. Journal of the Royal Society Interface,2009,6(32): 279-291.
    MAMMANO F, ASHMORE J F. Differential expression of outer hair cell potassium currents in the isolated cochlea of the guinea-pig[J]. The Journal of Physiology,1996,496(3): 639-646.
    KROS C J, RUSCH A, RICHARDSON G P. Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea[J]. Proceedings of the Royal Society of London B: Biological Sciences,1992,249(1325): 185-193.
    MOUJAHID A, D’ANJOU A, TORREALDEA F J, et al. Energy and information in Hodgkin-Huxley neurons[J]. Physical Review E,2011,83(3): 031912. DOI:10.1103/PhysRevE.83.031912.
    WANG Y, WANG R, XU X. Neural energy supply-consumption properties based on Hodgkin-Huxley model[J]. Neural Plasticity,2017,2017: 6207141. DOI: 10.1155/2017/6207141.
    PALMER A R, RUSSELL I J. Phase-locking in the cochlear nerve of the guinea-pig and its relation to the receptor potential of inner hair-cells[J]. Hearing Research,1986,24(1): 1-15.
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