留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

一种剪应力作用下ATP调节的血管内皮细胞内钙离子动力学数学模型

胡徐趣 向程 曹玲玲 许喆 覃开蓉

胡徐趣, 向程, 曹玲玲, 许喆, 覃开蓉. 一种剪应力作用下ATP调节的血管内皮细胞内钙离子动力学数学模型[J]. 应用数学和力学, 2008, 29(10): 1172-1180.
引用本文: 胡徐趣, 向程, 曹玲玲, 许喆, 覃开蓉. 一种剪应力作用下ATP调节的血管内皮细胞内钙离子动力学数学模型[J]. 应用数学和力学, 2008, 29(10): 1172-1180.
HU Xu-qu, XIANG Cheng, CAO Ling-ling, XU Zhe, QIN Kai-rong. A Mathematical Model for ATP-Mediated Calcium Dynamics in Vascular Endothelial Cells Induced by Fluid Shear Stress[J]. Applied Mathematics and Mechanics, 2008, 29(10): 1172-1180.
Citation: HU Xu-qu, XIANG Cheng, CAO Ling-ling, XU Zhe, QIN Kai-rong. A Mathematical Model for ATP-Mediated Calcium Dynamics in Vascular Endothelial Cells Induced by Fluid Shear Stress[J]. Applied Mathematics and Mechanics, 2008, 29(10): 1172-1180.

一种剪应力作用下ATP调节的血管内皮细胞内钙离子动力学数学模型

基金项目: 国家自然科学基金资助项目(10472027);新加坡国立大学学术研究基金资助项目(R-263-000-483-112)
详细信息
    作者简介:

    胡徐趣(1983- ),男,湖南石门人,硕士生;覃开蓉,研究员,博士(联系人.E-mail:eleqk@nus.edu.sg).

  • 中图分类号: Q66;Q81;Q351.2

A Mathematical Model for ATP-Mediated Calcium Dynamics in Vascular Endothelial Cells Induced by Fluid Shear Stress

  • 摘要: 考虑剪应力诱导血管内皮细胞钙离子内流主要取决于经由三磷酸腺苷(ATP)门控离子通道P2X4的钙离子内流这一实验事实,提出一个修正的剪应力诱导钙离子内流模型,认为钙离子内流量不仅取决于细胞膜内外钙离子浓度差,而且受细胞表面ATP浓度调节A·D2同时利用文献中公布的实验结果,建立了一个新的静态ATP分泌模型,并将其整合到修正后的钙离子内流模型中,建立了一个描述动脉内皮细胞内非线性钙离子动力学系统.求解整合后动力学系统的控制方程,可获得内皮细胞在剪应力作用下受ATP调节的钙离子响应.结果表明,与文献中其他模型比较,改进后的模型模拟的结果能更真实地反映实验事实.
  • [1] Ando J, Komatsuda T, Kamiya A. Cytoplasmic calcium responses to fluid shear stress in cultured vascular endothelial cells[J].In Vitro Cell Dev Biol,1988,24(9):871-877. doi: 10.1007/BF02623896
    [2] Davies P F. Flow-mediated endothelial mechanotransduction[J].Physiol Rev,1995,75(3):519-560.
    [3] Dull R O, Davies P F. Flow modulation of agonist (ATP)-response (Ca2+) coupling in vascular endothelial cells[J].Am J Physiol,1991,261(1Pt2):H149-H156.
    [4] Mo M, Eskin S G,Schilling W P. Flow-induced changes in calcium signaling of vascular endothelial cells:effects of shear stress and ATP[J].Am J Physiol,1991,260(5Pt2): H1698-H1707.
    [5] Yamamoto K, Sokabe T, Ohura N,et al.Endogenously released ATP mediates shear-stress-induced Ca2+ influx into pulmonary artery endothelial cells[J].Am J Physiol,2003,285(2):H793-H803.
    [6] Wiesner T F, Berk B C,Nerem R M.A mathematical model of the cytosolic-free calcium response in endothelial cells to fluid shear stress[J].PNAS,1997,94(8):3726-3731. doi: 10.1073/pnas.94.8.3726
    [7] Shi X M, Zheng Y F, Liu Z R,et al.A model of calcium signaling and degranulation dynamics induced by laser irradiation in mast cells[J].Chinese Science Bulletin,2008,53(15):2315-2325. doi: 10.1007/s11434-008-0255-z
    [8] John K, Barakat A I. Modulation of ATP/ADP concentration at the endothelial surface by shear stress: effect of flow-induced ATP release[J].Ann Biomed Eng,2001,29(9):740-751. doi: 10.1114/1.1397792
    [9] Plank M J, Wall D J N, David T. Atherosclerosis and calcium signaling in endothelial cells[J].Prog Biophys Mol Biol,2006,91(3): 287-313. doi: 10.1016/j.pbiomolbio.2005.07.005
    [10] Kumar V, Pandey R N,Upadhyay S N. A closed form solution of convective mass transfer model for intracellular calcium response of endothelial cells[J].Mathematical Problems in Engineering,1998,4(5):437-459. doi: 10.1155/S1024123X9800091X
    [11] Qin K R, Xiang C, Xu Z,et al.Dynamic modeling for shear stress induced ATP release from vascular endothelial cells[J].Biomech Model Mechanobiol,2008,7(5):345-353. doi: 10.1007/s10237-007-0088-8
  • 加载中
计量
  • 文章访问数:  2300
  • HTML全文浏览量:  36
  • PDF下载量:  747
  • 被引次数: 0
出版历程
  • 收稿日期:  2007-08-22
  • 修回日期:  2008-09-03
  • 刊出日期:  2008-10-15

目录

    /

    返回文章
    返回