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双向流固耦合作用下狭窄左冠状动脉内两相血流分析

刘莹 张伟中 殷艳飞 张智亮 章德发

刘莹, 张伟中, 殷艳飞, 张智亮, 章德发. 双向流固耦合作用下狭窄左冠状动脉内两相血流分析[J]. 应用数学和力学, 2016, 37(5): 501-509. doi: 10.3879/j.issn.1000-0887.2016.05.006
引用本文: 刘莹, 张伟中, 殷艳飞, 张智亮, 章德发. 双向流固耦合作用下狭窄左冠状动脉内两相血流分析[J]. 应用数学和力学, 2016, 37(5): 501-509. doi: 10.3879/j.issn.1000-0887.2016.05.006
LIU Ying, ZHANG Wei-zhong, YIN Yan-fei, ZHANG Zhi-liang, ZHANG De-fa. 2-Phase Hemodynamic Analysis Under Bidirectional Fluid-Structure Interaction in the Left Coronary Artery With Stenosis[J]. Applied Mathematics and Mechanics, 2016, 37(5): 501-509. doi: 10.3879/j.issn.1000-0887.2016.05.006
Citation: LIU Ying, ZHANG Wei-zhong, YIN Yan-fei, ZHANG Zhi-liang, ZHANG De-fa. 2-Phase Hemodynamic Analysis Under Bidirectional Fluid-Structure Interaction in the Left Coronary Artery With Stenosis[J]. Applied Mathematics and Mechanics, 2016, 37(5): 501-509. doi: 10.3879/j.issn.1000-0887.2016.05.006

双向流固耦合作用下狭窄左冠状动脉内两相血流分析

doi: 10.3879/j.issn.1000-0887.2016.05.006
基金项目: 国家自然科学基金(51165031)
详细信息
    作者简介:

    刘莹(1957—),女,教授,博士,博士生导师(通讯作者. E-mail: lyingncu@163.com).

  • 中图分类号: Q66; O359; R312

2-Phase Hemodynamic Analysis Under Bidirectional Fluid-Structure Interaction in the Left Coronary Artery With Stenosis

Funds: The National Natural Science Foundation of China(51165031)
  • 摘要: 基于血流与血管壁间双向流固耦合作用,将血液设为两相流体,运用计算流体力学方法对左冠状动脉内血流进行瞬态数值模拟.研究了一个心动周期内典型时刻下左冠状动脉内血流分布特性,并与Newton(牛顿)血液和两相血液模型对比,分析了两相血液和流固耦合作用对血流特性的影响.结果表明,左冠状动脉左回旋支远段和钝缘支近心端外侧分布了低速涡流区,该区域内壁面切应力和红细胞体积分数均较小,为动脉粥样硬化的形成与发展提供了合适的生理环境.左冠状动脉分叉处管壁形变量较大,引起管壁内膜功能发生紊乱,促进了粥样硬化斑块的形成.3种血液模型对比可知,红细胞的流动特性对血流速度及壁面切应力等血流动力学特性影响较大,双向流固耦合模型更符合真实的血液流动情况.
  • [1] 陈伟伟, 高润霖, 刘力生, 朱曼璐, 王文, 王拥军, 吴兆苏, 胡盛寿. 中国心血管病报告2013概要[J]. 中国循环杂志, 2014,7(29): 487-491.(CHEN Wei-wei, GAO Run-lin, LIU Li-sheng, ZHU Man-lu, WANG Wen, WANG Yong-jun, WU Zhao-su, HU Sheng-shou. Summary of report on cardiovascular diseases in China 2013[J]. Chinese Circulation Journal,2014,7(29): 487-491.(in Chinese))
    [2] Nixon A M, Gunel M, Sumpio B E. The critical role of hemodynamics in the development of cerebral vascular disease: a review[J]. Journal of Neurosurgery,2010,〖STHZ〗 112(6): 1240-1253.
    [3] 杨金有, 俞航, 刘静, 洪洋. 椎动脉狭窄内血液两相流动数值模拟分析[J]. 现代生物医学进展, 2014,14(18): 3410-3413.(YANG Jin-you, YU Hang, LIU Jing, HONG Yang. Numerical simulation in two-phase blood flow in stenosis of vertebral artery[J]. Progress in Modern Biomedicine,2014,14(18): 3410-3413.(in Chinese))
    [4] 刘莹, 章德发, 毕勇强, 王梦洪. 主动脉弓及分支血管内非稳态血流分析[J]. 应用数学和力学, 2015,36(4): 432-439.(LIU Ying, ZHANG De-fa, BI Yong-qiang, WANG Meng-hong. Analysis of unsteady blood flow in the human aortic bifurcation[J]. Applied Mathematics and Mechanics,2015,36(4): 432-439.(in Chinese))
    [5] Tomaiuolo G. Biomechanical properties of red blood cells in health and disease towards microfluidics[J]. Biomicrofluidics,2014,8(5): 051501-1-051501-19.
    [6] Filipovic N, TENG Zhong-zhao, Radovic M, Saveljic I, Fotiadis D, Parodi O. Computer simulation of three-dimensional plaque formation and progression in the carotid artery[J]. Medical & Biological Engineering & Computing,2013,51(6): 607-616.
    [7] 杨关林, 王凤荣. 冠心病[M]. 北京: 中国中医药出版社, 2010.(YANG Guan-lin, WANG Feng-rong.Coronary Heart Disease [M]. Beijing: China Press of Traditional Chinese Medicine, 2010.(in Chinese))
    [8] Cebral J R, Mut F, Sforza D, Lhner R, Scrivano E, Lylyk P, Putman C. Clinical application of image-based CFD for cerebral aneurysms[J]. International Journal for Numerical Methods in Biomedical Engineering,2011,27(7): 977-992.
    [9] 周俊波, 刘洋. FLUENT6.3流场分析从入门到精通[M]. 北京: 机械工业出版社, 2012.(ZHOU Jun-bo, LIU Yang. FLUENT6.3 Analysis of Flow Field From Entry to the Master[M]. Beijing: China Machine Press, 2012.(in Chinese))
    [10] 李昳. 离心泵内部固液两相流动数值模拟与磨损特性研究[D]. 杭州: 浙江理工大学, 2014.(LI Yi. The research on numerical simulation and abrasion property of solid-liquid two-phase-flow centrifugal pump[D]. PhD Thesis. Hangzhou: Zhejiang Sci-Tech University, 2014.(in Chinese))
    [11] LIU Bi-yue. The influences of stenosis on the downstream flow pattern in curved arteries[J]. Medical Engineering & Physics,2007,29(8): 868-876.
    [12] WU Wei-tao, Aubry N, Massoudi M. On the coefficients of the interaction forces in a two-phase flow of a fluid infused with particles[J]. International Journal of Non-Linear Mechanics,2014,59: 76-82.
    [13] SUN An-qiang, FAN Yu-bo, DENG Xiao-yan. Numerical study of hemodynamics at coronary bifurcation with and without swirling flow[C]// Proceedings of 6th World Congress of Biomechanics.Singapore, 2010: 1428-1430.
    [14] Amblard A, Walter-Le Berre H, Bou-Sad B, Brunet M. Analysis of type I endoleaks in a stented abdominal aortic aneurysm[J]. Medical Engineering & Physics,2009,31(1): 27-33.
    [15] 刘纯, 白象忠, 李小宝. 狭窄血管处管壁的变形与应力分析[J]. 工程力学, 2013,30(2): 464-469.(LIU Chun, BAI Xiang-zhong, LI Xiao-bao. Deformation and stress analysis of stenosed vessels[J]. Engineering Mechanics,2013,30(2): 464-469.(in Chinese))
    [16] Jung J, Lyczkowski R W, Panchal C B, Hassanein A. Multiphase hemodynamic simulation of pulsatile flow in a coronary artery[J].Journal of Biomechanics,2006,39(11): 2064-2073.
    [17] HOU Yun-long, Wischgoll T, Kassab G S. Flow patterns in three-dimensional porcine epicardial coronary arterial tree[J].American Journal of Physiology—Heart and Circulatory Physiology,2007,293(5): 2959-2970.
    [18] 宋江湖, 陈国定, 任延平. 考虑流固耦合作用的主动脉弓血液流动分析[J]. 中国生物医学工程学报, 2008,27(3): 405-409.(SONG Jiang-hu, CHEN Guo-ding, REN Yan-ping. Blood flow analysis in aortic arch with fluid-structure interaction[J]. Chinese Journal of Biomedical Engineering,2008,27(3): 405-409.(in Chinese))
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出版历程
  • 收稿日期:  2015-09-09
  • 修回日期:  2016-01-26
  • 刊出日期:  2016-05-15

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